Fire and Rescue personnel were called along with HazMat crews following a reported crash that led to major lane closures in the northbound lanes of the interstate between exits 33 and 36 in Parkton.
According to officials, there were "serious injuries" and I-83 was closed at York Road amid the ongoing investigation and cleanup.
Details about the crash are expected to be released.
This is a developing story. Check Daily Voice for updates.
Want breaking news in the DMV as it happens, or want to contribute? Join the DMV All Incidents Facebook group.
Click here to follow Daily Voice Frederick and receive free news updates.